Publications

Bexte, T., Albinger, N., Al Ajami, A., Wendel, P., Buchinger, L., Gessner, A., Alzubi, J., Särchen, V., Vogler, M., Rasheed, H.M., Jung, B.A., Wolf, S., Bhayadia, R., Oellerich, T., Klusmann, J.H., Penack, O., Möker, N., Cathomen, T., Rieger, M.A., Imkeller, K., Ullrich, E. (2024) CRISPR/Cas9 editing of NKG2A improves the efficacy of primary CD33-directed chimeric antigen receptor natural killer cells. Nat Commun. 15(1):8439-.

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Weiss, L.M., Warwick, T., Zehr, S., Günther, S., Wolf, S., Schmachtel, T., Izquierdo Ponce, J., Pálfi, K., Teichmann, T., Schneider, A., Stötzel, J., Knapp, S., Weigert, A., Savai, R., Rieger, M.A., Oellerich, T., Wittig, I., Oo, J.A., Brandes, R.P., Leisegang, M.S. (2024) RUNX1 interacts with lncRNA SMANTIS to regulate monocytic cell functions. Commun Biol. 13;7(1):1131.

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Blaheta, R.A., Han, J., Oppermann, E., Bechstein, W.O., Burkhard, K., Haferkamp, A., Rieger, M.A., Malkomes, P. (2025) Transglutaminase 2 promotes epithelial-to-mesenchymal transition by regulating the expression of matrix metalloproteinase 7 in colorectal cancer cells via the MEK/ERK signaling pathway. Biochim Biophys Acta Mol Basis Dis. 1871(1):167538.

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Hernandez-Olmos, V., Heering, J., Marinescu, B., Schermeng, T., Ivanov, V.V., Moroz, Y.S., Nevermann, S., Mathes, M., Ehrler, J.H.M., Wessam Alnouri, M., Wolf, M., Haydo, A.S., Schmachtel, T., Zaliani, A., Höfner, G., Kaiser, A., Schubert-Zsilavecz, M., Beck-Sickinger, A.G., Offermanns, S., Gribbon, P., Rieger, M.A., Merk, D., Sisignano, M., Steinhilber, D., Proschak, E. (2024) Development of a Potent and Selective G2A (GPR132) Agonist. J Med Chem 67(13):10567-10588.

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Enssle, J.C., Campe, J., Moter, A., Voit, I., Gessner, A., Yu, W., Wolf, S., Steffen, B., Serve, H., Bremm, M., Huenecke, S., Lohoff, M., Vehreschild, M., Rabenau, H.F., Widera, M., Ciesek, S., Oellerich, T., Imkeller, K., Rieger, M.A., von Metzler, I., Ullrich, E. (2024). Cytokine-responsive T- and NK-cells portray SARS-CoV-2 vaccine-responders and infection in multiple myeloma patients. Leukemia 38:168–180

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Yalcin, B.H., Macas, J., Wiercinska, E., Harter, P.N., Fawaz, M., Schmachtel, T., Ghiro, I., Bieniek, E., Kosanovic, D., Thom, S., Fruttiger, M., Taketo, M.M., Schermuly, R.T., Rieger, M.A., Plate, K.H., Bonig, H., Liebner, S. (2023) Wnt/β-Catenin-Signaling Modulates Megakaryopoiesis at the Megakaryocyte-Erythrocyte Progenitor Stage in the Hematopoietic System. Cells 12(23):2765. doi: 10.3390/cells12232765

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Malkomes, P., Lunger, I., Oppermann, E., Lorenz, J., Faqar-Uz-Zaman, S.F., Han, J., Bothur, S., Ziegler, P., Bankov, K., Wild, P., Bechstein, W.O., and Rieger, M.A.. (2023)
Transglutaminase 2 is associated with adverse colorectal cancer survival and represents a therapeutic target.
Cancer Gene Ther ePub ahead of print
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Burger, M.C., Forster, M.T., Romanski, A., Straßheimer, F., Macas, J., Zeiner, P.S., Steidl, E., Herkt, S., Weber, K.J., Schupp, J., Lun, J.H., Strecker, M.I., Wlotzka, K., Cakmak, P., Opitz, C., George, R., Mildenberger, I.C., Nowakowska, P., Zhang, C., Röder, J., Müller, E., Ihrig, K., Langen, K.J., Rieger, M.A., Herrmann, E., Bönig, H., Harter, P.N., Reiss, Y., Hattingen, E., Rödel, F., Plate, K.H., Tonn, T., Senft, C., Steinbach, J.P., Wels, W.S. (2023)
Intracranial injection of NK cells engineered with a HER2-targeted chimeric antigen receptor in patients with recurrent glioblastoma.
Neuro Oncol 6:noad087
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Mas-Peiro, S., Pergola, G., Berkowitsch, A., Meggendorfer, M., Rieger, M.A., Vasa-Nicotera, M., Dimmeler, S., Zeiher, A.M. (2023)
Long-term risk associated with clonal hematopoiesis in patients with severe aortic valve stenosis undergoing TAVR.
Clin Res Cardiol. 112(5):585-593.
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Külp, M., Larghero, P., Alten, J., Cario, G., Eckert, C., Caye-Eude, A., Cavé, H., Schmachtel, T., Bardini, M., Cazzaniga, G., De Lorenzo, P., Valsecchi, M.G., Bonig, H., Meyer, C., Rieger, M.A., Marschalek, R. (2023)
The EGR3 regulome of infant KMT2A-r acute lymphoblastic leukemia identifies differential expression of B-lineage genes predictive for outcome.
Leukemia 37(6):1216-1233.
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Rieger, M.A.. (2022)
Einfluss der klonalen Hämatopoese auf nicht-hämatologische Erkrankungen und Alterungsprozesse.
Die Innere Medizin 63(11):1115-25. (German)
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Bogeska, R. Mikecin, A.M., Kaschutnig, P., Fawaz, M., Büchler-Schäff, M., Le, D., Ganuza, M., Vollmer, A., Paffenholz, S.V., Asada, N., Rodriguez-Correa, E., Frauhammer, F., Buettner, F., Ball, M., Knoch, J., Stäble, S., Walter, D., Petri, A., Carreño-Gonzalez, M.J., Wagner, V., Brors, B., Haas, S., Lipka, D.B. Essers, M.A.G., Weru, V., Holland-Letz, T., Mallm, J.-P., Rippe, K., Krämer, S., Schlesner, M., McKinney Freeman, S., Florian, M.C., King, K.J., Frenette, P.S., Rieger, M.A., Milsom, M.D. (2022)
Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging.
Cell Stem Cell 29(8):1273-1284
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Cremer, A., Abplanalp, W.T., Rieger, M.A.. (2022)
Time´s up: Time's up: mutation rate and lifespan.
Signal Transduct Target Ther 7(1):282.
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Kuhnert, S., Mansouri, S., Rieger, M.A., Savai, R., Avci, E., Díaz-Piña, G., Padmasekar, M., Looso, M., Hadzic, S., Acker, T., Klatt, S., Wilhelm, J., Fleming, I., Sommer, N., Weissmann, N., Vogelmeier, C., Bals, R., Zeiher, A., Dimmeler, S., Seeger, W., Pullamsetti, S.S. (2022)
Association of Clonal Hematopoiesis of Indeterminate Potential with Inflammatory Gene Expression in Patients with COPD.
Cells 11:2121.
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Enssle, J., Campe, J., Büchel, S., Moter, A., See, F., Grießbaum, K., Rieger, M.A., Wolf, S., Ballo, O., Steffen, B., Serve, H., Rabenau, H.F., Widera, M., Bremm, M., Huenecke, S., Ciesek, S., von Metzler, I., Ullrich, E. (2022)
Enhanced but variant-dependent serological and cellular immune responses to third-dose BNT162b2 vaccination in patients with multiple myeloma.
Cancer Cell 40(6):587-589.
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Enssle, J.C., Campe, J., Schwenger, A., Wiercinska, E., Hellstern, H., Dürrwald, R., Rieger, M.A., Wolf, S., Ballo, O., Steffen, B., Serve, H., Bonig, H., Rabenau, H.F., Widera, M., Ciesek, S., Metzler, I., Ullrich, E. (2022)
Severe impairment of T-cell responses to BNT162b2 immunization in multiple myeloma patients.
BLOOD 139(1):137–142.
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Bartsch, L., Schroeder, M.P., Hänzelmann, S., Bastian, L., Lázaro-Navarro, J., Schlee, C., Tanchez, J.O., Schulze, V., Isaakidis, K., Rieger, M.A., Gökbuget, N., Eckert, C., Serve, H., Horstmann, M., Schrappe, M., Brüggemann, M., Baldus, C.D., Neumann, M. (2022)
An alternative CYB5A transcript is expressed in aneuploid ALL and enriched in relapse.
BMC Genom Data 23(1):30.
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Lazaro-Navarro, J., Pimentel-Gutiérrez, H.J., Gauert, A., Hagemann, A., Eisenschmid, J.L., Goekbuget, N., Vick, B., Jeremias, I., Seyfried, F., Meyer, L.H., Debatin, K.-M., Richter, K., Bultmann, M., Neumann, M., Haenzelmann, S., Serve, H., Astrahantseff, K., Rieger, M.A., Eckert, C., Baldus, C.D., Bastian, L. (2021)
Inhibiting Casein Kinase 2 Sensitizes Acute Lymphoblastic Leukemia Cells to Venetoclax Via MCL1 Degradation.
BLOOD Adv. 5(24):5501–5506.
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Malkomes, P.*, Lunger, I.*, Oppermann, E., Abou-El-Ardat, K., Oellerich, T., Günther, S., Canbulat, C., Bothur, S., Schnütgen, F., Yu, W., Wingert, S., Haetscher, N., Catapano, C., Dietz, M.S., Heilemann, M., Kvasnicka, H.-M., Holzer, K., Serve, H., Bechstein, W. O., Rieger, M.A. (2021)
Transglutaminase 2 promotes tumorigenicity of colon cancer cells by inactivation of the tumor suppressor p53.
Oncogene 40:4352–4367.
* shared first authorship
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Schmidt, J., Oppermann, E., Blaheta, R.A., Schreckenbach, T., Lunger, I., Rieger, M.A., Bechstein, W.O., Holzer, K., Malkomes, P. (2021)
Carbonic-anhydrase IX expression is increased in thyroid cancer tissue and represents a potential therapeutic target to eradicate thyroid tumor-initiating cells.
Mol Cell Endocrinol 535:111382.
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Rieger, M.A (2021)
A heartbreaking relationship: clonal hematopoiesis and heart failure.
Trends Cardiovasc Med S1050-1738(21)00053-0.
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Le Mercier, A., Bonnavion, R., Yu, W., Alnouri, M.W., Ramas, S., Zhang, Y., Jäger, Y., Roquid, K.A., Jeong, H.-W., Sivaraj, K.K., Cho, H, Chen, X., Strilic, B., Sijmonsma, T., Adams, R., Schroeder, T., Rieger, M.A., Offermanns, S. (2021)
GPR182 is an endothelium-specific atypical chemokine receptor that maintains hematopoietic stem cell homeostasis.
Proc Natl Acad Sci U S A 118(17):e2021596118.
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Kiefer, K.C., Cremer, S., Pardali, E., Assmus, B., Abou-El-Ardat, K., Kirschbaum, K., Dorsheimer, L., Rasper, T., Berkowitsch, A., Serve, H., Dimmeler, S.*, Zeiher, A.M.*, Rieger, M.A* (2021)
Full spectrum of clonal haematopoiesis‐driver mutations in chronic heart failure and their associations with mortality.
ESC Heart Failure 8:1873-1884.
* shared last authorship
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Abplanalp, W.T., John, D., Cremer, S., Assmus, B., Dorsheimer, L., Hoffmann, J., Becker-Pergola, G., Rieger, M.A., Zeiher, A.M., Vasa-Nicotera, M., Dimmeler, S. (2021)
Single cell RNA sequencing reveals profound changes in circulating immune cells in patients with heart failure.
Cardiovasc. Res. 117(2):484-494.
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Assmus, B., Cremer, S., Kirschbaum, K., Culmann, D., Kiefer, K., Dorsheimer, L., Rasper, T., Abou-El-Ardat, K., Herrmann, E., Berkowitsch, A., Hoffmann, J., Seeger, F., Mas-Peiro, S., Rieger, M.A., Dimmeler, S., Zeiher, A.M. (2021)
Clonal haematopoiesis in chronic ischaemic heart failure: prognostic role of clone size for DNMT3A- and TET2-driver gene mutations.
Eur. Heart J. 42(3):257-265.
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Abplanalp, W.T., Cremer, S., John, D., Hoffmann, J., Schuhmacher, B., Merten, M., Rieger, M.A., Vasa-Nicotera, M., Zeiher, A.M., Dimmeler, S. (2021)
Clonal Hematopoiesis-Driver DNMT3A Mutations Alter Immune Cells in Heart Failure.
Circ. Res. 128(2):216-228.
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Lauber, C., Correia, N., Trumpp, A., Rieger, M.A., Dolnik, A., Bullinger, L., Roeder, I., Seifert, M. (2020)
Survival differences and associated molecular signatures of DNMT3A-mutant acute myeloid leukemia patients.
Sci Rep 10(1):12761-77.
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Sommerkamp, P., Altamura, S., Renders, S., Narr, A., Ladel, L., Zeisberger, P., Eiben, P.L., Fawaz, M., Rieger, M.A., Cabezas-Wallscheid, N., Trumpp, A. (2020)
Differential Alternative Polyadenylation Landscapes Mediate Hematopoietic Stem Cell Activation and Regulate Glutamine Metabolism.
Cell Stem Cell 26(5):722-738.
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Pardali, E., Dimmeler, S., Zeiher, A.M., Rieger, M.A.# (2020)
Clonal hematopoiesis, aging, and cardiovascular diseases.
Exp. Hematol. 83:95-104.
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Mas-Peiro, S., Hoffmann, J., Fichtlscherer, S., Dorsheimer, L., Rieger, M.A., Dimmeler, S., Vasa-Nicotera, M., and Zeiher A.M. (2020)
Clonal haematopoiesis in patients with degenerative aortic valve stenosis undergoing transcatheter aortic valve implantation.
European Heart Journal , 41(8):933-939
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Dorsheimer, L.*, Assmus, B.*, Rasper, T., Ortmann, C.A., Abou-El-Ardat, K., Kiefer, K.C., Hoffmann, J., Seeger, F., Bonig, H., Dimmeler, S.#, Zeiher, A.M.#, Rieger, M.A.# (2020)
Hematopoietic alterations in chronic heart failure patients by somatic mutations leading to clonal hematopoiesis.
Haematologica e328-e332.
* shared first authorship
# shared senior authorship
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Rieger, M.A.*. (2019)
How children’s glue fixes a decades old enigma.
Annal. Transl. Med. doi: 10.21037/atm.2019.09.90
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Ortmann, C.A., Dorsheimer, L., Abou-El-Ardat. K., Hoffrichter, J., Assmus, B., Bonig, H., Scholz, A., Pfeifer, H., Martin, H., Schmid, T., Brüne, B., Scheich, S., Steffen, B., Riemann, J., Hermann, S., Dukat, A., Bug, G., Brandts, C.H., Wagner, S., Serve, H., Rieger, M.A. (2019)
Functional Dominance of CHIP-Mutated Hematopoietic Stem Cells in Patients Undergoing Autologous Transplantation.
Cell Rep 27(7):2022-2028.e3.
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Bastian, L., Schroeder, M.P., Eckert, C., Schlee, C., Tanchez, J.O., Kämpf, S., Wagner, D.L., Schulze, V., Isaakidis, K., Lázaro-Navarro, J., Hänzelmann, S., James, A.R., Ekici, A., Burmeister, T., Schwartz, S., Schrappe, M., Horstmann, M., Vosberg, S., Krebs, S., Blum, H., Hecht, J., Greif, P.A., Rieger, M.A., Brüggemann, M., Gökbuget, N., Neumann, M., Baldus, C.D. (2019)
PAX5 biallelic genomic alterations define a novel subgroup of B-cell precursor acute lymphoblastic leukemia.
Leukemia 33(8):1895-1909.
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Diefenhardt, M., Hofheinz, R.D., Martin, D., Beißbarth, T., Arnold, D., Hartmann, A., von der Grün, J., Grützmann, R., Liersch, T., Ströbel, P., Grabenbauer, G.G., Rieger, M., Fietkau, R., Graeven, U., Weitz, J., Folprecht, G., Ghadimi, M., Rödel, F., Rödel, C., Fokas, E.; German Rectal Cancer Study Group. (2019)
Leukocytosis and neutrophilia as independent prognostic immunological biomarkers for clinical outcome in the CAO/ARO/AIO-04 randomized phase 3 rectal cancer trial.
Int. J. Cancer 145(8):2282-2291.
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Schroeder, M.P., Bastian, L., Eckert, C., Gökbuget, N., James, A.R., Tanchez, J.O., Schlee, C., Isaakidis, K., Häupl, B., Baum, K., Migueles Lozano, O.A., Kouidri, K., Pan, K.T., Urlaub, H., Schwartz, S., Burmeister, T., von Stackelberg, A., Hoelzer, D., Pfeiffer, H., Rieger, M.A., Göllner, S., Oellerich, T., Horstman, M., Schrappe, M., Wolf, J., Kirschner-Schwabe, R., Brüggemann, M., Müller-Tidow, C., Serve, H., Neumann, M., Baldus, C.D. (2019)
Integrated analysis of relapsed B-cell precursor Acute Lymphoblastic Leukemia identifies subtype-specific cytokine and metabolic signatures.
Sci. Rep. 12;9(1):4188.
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Dorsheimer, L.*, Assmus, B. *, Rasper, T., Ortmann, C.A., Ecke, A., Abou-El-Ardat, K., Schmid, T., Brüne, B., Wagner, S., Serve, H., Hoffmann, J., Seeger, F., Dimmeler, S.#, Zeiher, A.M.#, Rieger, M.A.# (2019)
Association of Mutations Contributing to Clonal Hematopoiesis With Prognosis in Chronic Ischemic Heart Failure.
JAMA Cardiol. 4:25-33.
* shared first authorship
# shared senior authorship
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Editorial > link
Interview > link
Editorial Nat Rev Cardiol > link

James, A.R., Schroeder, M.P., Neumann, M., Bastian, L., Eckert, C., Gökbuget, N., Tanchez, J.O., Schlee, C., Isaakidis, K., Schwartz, S., Burmeister, T., von Stackelberg, A., Rieger, M.A., Göllner, S., Horstman, M., Schrappe, M., Kirschner-Schwabe, R., Brüggemann, M., Müller-Tidow, C., Serve, H., Akalin, A., Baldus, C.D. (2019)
Long non-coding RNAs defining major subtypes of B cell precursor acute lymphoblastic leukemia.
J Hematol Oncol. 12:8.
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Debaize, L., Jakobczyk, H., Avner, S., Gaudichon, J., Rio, A.G., Sérandour, A.A., Dorsheimer, L., Chalmel, F., Carroll, J.S., Zörnig, M., Rieger, M.A., Delalande, O., Salbert, G., Galibert, M.D., Gandemer, V., Troadec, M.B. (2018)
Interplay between transcription regulators RUNX1 and FUBP1 activates an enhancer of the oncogene c-KIT and amplifies cell proliferation.
Nucleic Acids Res. 46:11214-28.
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Bhayadia, R.*, , Krowiorz, K.*, Haetscher, N.*, Jammal, R.*, Emmrich, S.*, Obulkasim, A. Fiedler, J., Schwarzer, A., Rouhi, A., Heuser, M., Wingert, S., Bothur, S., Döhner, K., Mätzig, T., Ng, M., Reinhardt, D., Döhner, H., Zwaan, C. M., van den Heuvel-Eibrink, M. M., Heckl, D., Fornerod, M., Thum, T., Humphries, R. K., Rieger, M. A.#, Kuchenbauer, F.#, Klusmann, J.-H.#. (2018)
The endogenous tumor suppressor microRNA-193b: therapeutic and prognostic value in acute myeloid leukemia.
J Clin Oncol 36:1007-1016
* shared first authorship
# shared senior authorship
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Cencioni, C., Spallotta, F., Savoia, M., Kuenne, C., Guenther, S., Re, A., Wingert, S., Rehage, M., Sürün, D., Siragusa, M., Smith, J.G., Schnütgen, F., von Melchner, H., Rieger, M.A., Martelli, F., Riccio, A., Fleming, I., Braun, T., Zeiher, A.M., Farsetti, A., Gaetano, C. (2018)
Zeb1-Hdac2-eNOS circuitry identifies early cardiovascular precursors in naïve mouse embryonic stem cells.
Nat Commun 9:1281.
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Laban, H., Weigert, A., Zink, J., Elgheznawy, A., Schürmann, C., Günther, L., Abdel Malik, R., Bothur, S., Wingert, S., Bremer, R., Rieger, M.A., Brüne, B., Brandes, R.P., Fleming, I., Benz, P.M. (2018)
VASP regulates leukocyte infiltration, polarization, and vascular repair after ischemia.
J Cell Biol 217:1503-1519.
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Manavski, Y, Lucas, T., Glaser, S.F., Dorsheimer, L., Günther, S., Braun, T., Rieger, M.A., Zeiher, A.M., Boon, R.A., Dimmeler, S. (2018)
Clonal Expansion of Endothelial Cells Contributes to Ischemia-Induced Neovascularization.
Circ Res 122:670-677.
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Wojcik, B., Lang, F., and Rieger, M.A.. (2017)
On the hunt for B-cell lymphoblastic leukemia-initiating stem cells.
Oncotarget 8:108286-108287.
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Rezende, F., Moll, F., Walter, M., Helfinger, V., Hahner, F., Janetzko, P., Ringel, Ch., Weigert, A., Fleming, I., Weissmann, N., Kuenne, C., Looso, M., Rieger, M.A., Nawroth, P., Fleming, Th., Brandes, R., Schröder, K. (2017)
The NADPH organizers NoxO1 and p47phox are both mediators of diabetes-induced vascular dysfunction in mice.
Redox Biol 15:12-21.
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Lunger, I.*, Fawaz, M.*, and Rieger, M.A.. (2017)
Single cell analyses to reveal hematopoietic stem cell fate decisions.
FEBS Lett 591:2195-2212.
* shared first authorship
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Cabezas-Wallscheid, N., Buettner, F., Sommerkamp, P., Klimmeck, D., Ladel, L., Thalheimer, F.B., Pastor-Flores, D., Roma, L., Renders, S., Zeisberger, P., Przybylla, A., Schönberger, K., Scognamiglio, R., , Altamura, S., Florian, C., Fawaz, M., Vonficht, D., Tesio, M., Collier, P., Pavlinic, D., Geiger, H., Schroeder., T., Benes, V., Dick, T.P., Rieger, M.A., Stegle, O. and Trumpp, A. (2017)
Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy.
Cell 169:807-823.
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Mohr, S., Doebele, C., Comoglio, F., Berg, T., Beck, J., Bohnenberger, H., Alexe, G., Corso, J., Ströbel, P., Wachter, A., Beissbarth, T., Schnütgen, F., Cremer, A., Haetscher, N., Göllner, S., Rouhi, A., Palmqvist, L., Rieger, M.A., Schroeder, T., Bönig, H., Müller-Tidow, C., Kuchenbauer, F., Schütz, E., Green, A.R., Urlaub, H., Stegmaier, K., Humphries, R.K., Serve, H., Oellerich, T. (2017)
Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia.
Cancer Cell 31:549-562.
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Wesely, J., Steiner, M., Schnütgen, F., Kaulich, M., Rieger, M.A., Zörnig, M. (2017)
Delayed Mesoderm and Erythroid Differentiation of Murine Embryonic Stem Cells in the Absence of the Transcriptional Regulator FUBP1.
Stem Cells Int. 2017:5762301
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Lang, F.*, Wojcik, B.*, Bothur S., Knecht, C., Falkenburg, J.H.F., Schroeder, T., Serve, H., Ottmann, O.G., Rieger, M.A. (2017)
Plastic CD34 and CD38 expression in adult B-cell precursor acute lymphoblastic leukemia explains ambiguity of leukemia-initiating stem cell populations.
Leukemia 31:731–734.
* shared first authorship
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Malik, R.A., Zippel, N., Frömel, T., Heidler, J., Zukunft, S., Walzog, B., Ansari, N., Pampaloni, F., Wingert, S., Rieger, M.A., Wittig, I., Fisslthaler, B., Fleming, I. (2017)
AMP-activated protein kinase α2 in neutrophils regulates vascular repair via hypoxia-inducible factor-1α and a network of proteins affecting metabolism and apoptosis.
Circ Res 120:99-109.
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Latorre-Rey, L.J., Wintterle, S., Dütting, S., Kohlscheen, S., Abel, T., Schenk, F., Wingert, S., Rieger, M.A., Nieswandt, B., Heinz, N., Modlich, U. (2017)
Targeting expression to megakaryocytes and platelets by lineage-specific lentiviral vectors.
J Thromb Haemost 15:341-355.
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Steinhäuser, K., Klöble, P., Kreis, N.-N., Ritter, A., Friemel, A., Roth, S., Reichel, J.M., Michaelis, J., Rieger, M.A., Louwen, F., Oswald, F. and Yuan J. (2017)
Deficiency of RITA results in multiple mitotic defects by affecting microtubule dynamics.
Oncogene 36:2146-2159.
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Hoppe, P.S., Schwarzfischer, M., Loeffler, D., Kokkaliaris, K.D., Hilsenbeck, O., Moritz, N., Endele, M., Filipczyk, A., Gambardella, A., Ahmed, N., Etzrodt, M., Coutu, D.L., Rieger, M.A., Marr, C., Strasser, M.K., Schauberger, B., Burtscher, I., Ermakova, O., Bürger, A., Lickert, H., Nerlov, C., Theis, F.J., Schroeder, T. (2016)
Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios.
Nature 535(7611):299-302.
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Corso, J., Pan, K.T., Walter, R., Doebele, C., Mohr, S., Bohnenberger, H., Ströbel, P., Lenz, C., Slabicki, M., Hüllein, J., Comoglio, F., Rieger, M.A., Zenz, T., Wienands, J., Engelke, M., Serve, H., Urlaub, H., Oellerich, T. (2016)
Elucidation of tonic and activated B-cell receptor signaling in Burkitt's lymphoma provides insights into regulation of cell survival.
Proc Natl Acad Sci U S A. 113(20):5688-93.
> pubmed

Kreis, N.-N., Friemel, A., Zimmer, B., Roth, S., Rieger, M.A., Rolle, U., Louwen, F., and Yuan, J. (2016)
Mitotic p21Cip1/CDKN1A is regulated by cyclin-dependent kinase 1 phosphorylation.
Oncotarget 7:50215-50228.
> pubmed

Wingert, S., Rieger, M.A. (2016)
Terminal differentiation induction as DNA damage response in hematopoietic stem cells by GADD45A.
Exp Hematol. 44:561-6.
> pubmed

Derlet, A., Rasper, T., Roy Choudhury, A., Bothur, S., Rieger, M.A., Namgaladze, D., Fischer, A., Schürmann, C., Brandes, R.P., Tschulena, U., Steppan, S., Assmus, B., Dimmeler, S., Zeiher, A.M., and Seeger, F.H. (2016)
Metabolism Regulates Cellular Functions of Bone Marrow-Derived Cells used for Cardiac Therapy.
Stem Cells 34:2236-48.
> pubmed

Malkomes, P., Lunger, I., I., Luetticke, A., Oppermann, E., Haetscher, N., Serve, H., Holzer, K., Bechstein, W.O. and Rieger, M.A. (2016)
Selective AKT inhibition by MK-2206 represses colorectal cancer-initiating stem cells.
Ann Surg Oncol 23:2849-57.
> pubmed

Wingert, S., Thalheimer, F.B., Haetscher, N., Rehage, M., Schroeder, T., and Rieger, M.A. (2016)
The DNA-damage response gene GADD45A induces differentiation in hematopoietic stem cells without inhibiting cell cycle or survival.
Stem Cells 34:699-710.
> pubmed

Haetscher, N.*, Feuermann, Y.*, Wingert, S., Rehage, M., Thalheimer, F.B., Weiser, C., Bohnenberger, H., Jung, K., Schroeder, T., Serve, H., Oellerich, T., Hennighausen, L., and Rieger, M.A. (2015)
STAT5-regulated microRNA-193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling.
Nature Commun. 6:8928.
* shared first authorship
> pubmed

Rieger, M.A. (2015)
ATF4, a new player in fetal HSC expansion.
Blood. 126 (21):2351-52.
> pubmed

Lang, F., Wojcik, B., and Rieger, M.A. (2015)
Stem Cell Hierarchy and Clonal Evolution in Acute Lymphoblastic Leukemia.
Stem Cells Int. 2015:137164
> pubmed

Rabenhorst, U.*, Thalheimer, F.B.*, Gerlach, K.*, Kijonka, M., Böhm, S., Krause, D., Vauti, F., Arnold, HH., Schroeder, T., Schnütgen, F., von Melchner, H., Rieger, M.A.#, and Zörnig, M#. (2015)
Single-stranded DNA-binding transcriptional regulator FUBP1 is essential for fetal and adult hematopoietic stem cell self-renewal.
Cell Reports 11(12):1847-55.
* shared first authorship
# shared senior authorship
> pubmed

Zhang, J., Vakhrusheva,O., Bandi, S.R., Demirel, Ö., Kazi,J.U., Fernandes, R.G., Jakobi, K., Eichler, A., Rönnstrand, L., Rieger, M.A., Carpino, N., Serve, H., and Brandts, C.H. (2015)
STS1 and STS2 are key regulators of hematopoietic stem and progenitor cell fitness.
Stem Cell Rep 5(4):633-46.
> pubmed

Kuvardina, O.N., Herglotz, J., Kolodziej, S., Kohrs, N., Herkt, S., Wojcik, B., Oellerich, T., Corso, J., Behrens, K., Kumar, A., Hussong, H., Urlaub, H., Koch, J., Serve, H., Bonig, H., Stocking, C., Rieger, M.A. and Lausen, J. (2015)
RUNX1 represses the erythroid gene expression program during megakaryocytic differentiation.
BLOOD 125(23):3570-9.
> pubmed

Walter, D., Lier, A., Geiselhart, A., Thalheimer, F.B., Huntscha, S., Sobotta, M., Moehrle, B., Brocks, D., Bayindir, I., Kaschutnig, P., Muedder, K., Klein, C., Jauch, A., Schroeder, T., Geiger, H., Dick, T., Holland-Letz, T., Schmezer, P., Lane, S., Rieger, M.A. Essers, M., Williams, D., Trumpp, A., and Milsom, M. (2015)
Exit from dormancy provokes de novo DNA damage-induced cellular attrition in haematopoietic stem cells.
Nature 520(7548):549-52.
> pubmed

Meinhardt, K., Kroeger, I., Bauer, R., Ganss, F., Ovsiy, I., Rothamer, J., Büttner, M., Atreya, I., Waldner, M., Bittrich, M., Lehmann, C.H., Rieger, M.A., Beilhack, A., Zeiser, R., Edinger, M., Dudziak, D., Mackensen, A., Rehli, M., and Ullrich, E. (2015)
Identification and characterization of the specific murine NK cell subset supporting graft-versus-leukemia- and reducing graft-versus-host-effects.
Oncoimmunology 4(1):e981483.
> pubmed

Schönfeld, K., Sahm. C., Zhang, C., Naundorf, S., Brendel, C., Odendahl, M., Nowakowska, P., Bönig, H., Köhl, U., Kloess, S., Köhler, S., Holtgreve-Grez, H., Jauch, A., Schmidt, M., Schubert, R., Kühlcke, K., Seifried, E., Klingemann, H.G., Rieger, M.A., Tonn, T., Grez, M., Wels, W.S. (2014)
Selective Inhibition of Tumor Growth by Clonal NK Cells Expressing an ErbB2/HER2-Specific Chimeric Antigen Receptor
Mol Ther 23(2):330-8.
> pubmed

Thalheimer, F.B., Wingert, S., De Giacomo, P., Haetscher, N., Rehage, M., Brill, B., Theis, F.J., Hennighausen, L., Schroeder, T., Rieger, M.A. (2014)
Cytokine-Regulated GADD45G Induces Differentiation and Lineage Selection in Hematopoietic Stem Cells
Stem Cell Reports 3(1):34-43.
> pubmed

Rengstl, B., Rieger, M.A.*, Newrzela, S.* (2014)
On the origin of giant cells in Hodgkin lymphoma
Communicative & Integrative Biology 7:I, e28602.
* shared last authorship
> pubmed

Rengstl, B., Newrzela, S., Heinrich, T., Weiser, C., Thalheimer, F.B., Schmid, F., Warner, K., Hartmann, S., Schroeder, T., Küppers, R., Rieger, M.A.*, Hansmann, M.L.* (2013)
Incomplete cytokinesis and re-fusion of small mononucleated Hodgkin cells lead to giant multinucleated Reed-Sternberg cells.
Proc Natl Acad Sci U S A. 110:20729-34.
* shared last authorship
> pubmed

Feuermann, Y., Kang, K., Gavrilova, O., Haetscher, N., Jin Jang, S., Yoo, K.H., Jiang, C., Gonzalez, F.J., Robinson, G.W., Hennighausen, L. (2013)
MiR-193b and miR-365-1 are not required for the development and function of brown fat in the mouse.
RNA Biol. [Epub ahead of print]
> pubmed

Kreis, N.N., Sanhaji, M., Rieger, M.A., Louwen, F., Yuan, J. (2013)
p21Waf1/Cip1 deficiency causes multiple mitotic defects in tumor cells.
Oncogene. [Epub ahead of print]
> pubmed

Ohtani, K., Zhao, C., Dobreva, G., Manavski, Y., Kluge, B., Braun, T., Rieger, M.A., Zeiher, A.M., Dimmeler, S. (2013)
Jmjd3 Controls Mesodermal and Cardiovascular Differentiation of Embryonic Stem Cells.
Circ Res. 113:856-62.
> pubmed

Oellerich, T., Oellerich, M.F., Engelke, M., Münch, S., Mohr, S., Nimz, M., Hsiao, H.H., Corso, J., Zhang, J., Bohnenberger, H., Berg, T., Rieger, M.A., Wienands, J., Bug, G., Brandts, C., Urlaub, H., and Serve, H. (2013)
ß2 integrin-derived signals induce cell survival and proliferation of AML blasts by activating a Syk/STAT signaling axis.
Blood, 121:3889-99.
> pubmed

Rieger, M.A. and Schroeder, T. (2012)
Hematopoiesis.
Cold Spring Harb Perspect Biol 4:a008250. Editors: Patrick P.L. Tam, W. James Nelson, and Janet Rossant
> pubmed

Eißmann, M., Melzer, I.M., Fernández, S.B., Michel, G., Hrabe de Angelis, M., Hoefler, G., Finkenwirth, P., Jauch, A., Schoell, B., Grez, M., Schmidt, M., Bartholomae, C.C., Newrzela, S.,Haetscher, N., Rieger, M.A., Zachskorn, C., Mittelbronn, M. and Zörnig, M. (2012)
Overexpression of the anti-apoptotic protein AVEN contributes to increased malignancy in hematopoietic neoplasms.
Oncogene [Epub ahead of print]
> pubmed

Ninkovic, J., Pinto, L., Petricca, S., Lepier, A., Sun, J., Rieger, M.A., Schroeder, T., Cvekl, A., Favor, J. and Götz, M. (2010)
The transcription factor Pax6 regulates survival of dopaminergic olfactory bulb neurons via crystallin a.
Neuron, 68: 682-94.
> pubmed

Rieger, M.A. and Schroeder, T. (2009)
Instruction of lineage choice by hematopoietic cytokines.
Cell Cycle, 8: 4019 – 4020.
> pubmed

Rieger, M.A., Hoppe, P.S., Smejkal, B.M., Eitelhuber, A.C. and Schroeder, T. (2009)
Hematopoietic cytokines can instruct lineage choice.
Science, 325: 217-218.
> pubmed

(P)Reviews in scientific journals:

• Science Signaling
• Nature Reports Stem Cells
• Nature Reviews Immunology
• Cell Stem Cell
• Nature
• recommended by the Faculty of 1000 Biology

Kimura, A.*, Rieger, M.A.*, Simone, J.M., Chen, W., Wickre, M.C., Zhu, B.-M., Hoppe, P.S., O’Shea, J., Schroeder, T.** and Hennighausen, L.** (2009)
The transcription factors STAT5A/B regulate GM-CSF-mediated granulopoiesis.
Blood, 114: 4721-8.
* and ** equal contributions
> pubmed

Rieger, M.A. and Schroeder, T. (2009)
Analysing cell fate control by cytokines through continuous single cell biochemistry.
Journal of Cellular Biochemistry, 108: 343 – 352.
> pubmed

Rieger, M.A., Smejkal, B.M. and Schroeder T (2009)
Improved prospective identification of megakaryocyte-erythrocyte progenitor cells.
British Journal of Haematology, 144: 448 – 451.
> pubmed

Rieger, M.A. and Schroeder, T. (2008)
Exploring hematopoiesis at single cell resolution.
Cells Tissues Organs, 188: 139-49.
> pubmed

Arakawa, H., Kudo, H., Batrak, V., Caldwell, R.B., Rieger, M.A., Ellwart, J.W. and Buerstedde, J.M. (2007)
Protein evolution by hypermutation and selection in the B cell line DT40.
Nucleic Acids Research, 36:e1.
> pubmed

Rieger M.A. and Schroeder, T. (2007)
Hämatopoetische Stammzellen, Review (German).
Biospektrum, 3.2007: 254-256.
> pubmed

Schmitz, M., Wehner, R., Stevanovic, S., Kießling, A., Rieger M.A., Temme, A., Bachmann, M., Rieber, E.P., and Weigle, B. (2007)
Identification of a naturally processed T cell epitope derived from the glioma-associated protein SOX11.
Cancer Lett. 245: 331-6.
> pubmed

Cappello, S., Attardo, A., Wu, X., Iwasato, T., Itohara, S., Wilsch-Brauninger, M., Eilken, H.M., Rieger M.A., Schroeder, T.T., Huttner, W.B., Brakebusch, C., and Gotz, M. (2006)
The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface.
Nature Neuroscience 9, 1099-107.
> pubmed

Weigle, B., Ebner, R., Temme, A., Schwind, S., Schmitz, M., Kiessling, A., Rieger M.A., Schackert, G., Schackert, H.K., and Rieber, E.P. (2005)
Highly specific overexpression of the transcription factor SOX11 in human malignant gliomas.
Oncol. Rep., 13, 139-144
> pubmed

Temme, A., Morgenroth, A., Diestelkoetter-Bachert, P., Weigle, B., Rieger M.A., Kiessling, A., Schmitz, M., and Rieber, E.P. (2005)
Increased p21ras activity in human fibroblasts transduced with Survivin enhances cell proliferation.
Biochem. Biophys. Res. Commun., 327, 765-773.
> pubmed

Temme, A., Herzig, E., Weigle, B., Morgenroth, A., Schmitz, M., Kiessling, A., Rieger, M.A., Schackert, H.K., and Rieber, E.P. (2005)
Inhibition of malignant glioma cell growth by a survivin mutant retrovirus.
Hum. Gene. Ther., 16, 209-222.
> pubmed

Schmitz, M., Zhao, S., Deuse, Y., Schäkel, K., Wehner, R., Wöhner, H., Hölig, K., Wienforth, F., Kiessling, A., Bornhäuser, M., Temme, A., Rieger, M.A., Weigle, B., Bachmann, M., and Rieber, E.P. (2005)
Tumoricidal potential of native blood dendritic cells: direct tumor cell killing and activation of NK cell-mediated cytotoxicity.
J. Immunol., 174, 4127-4134.
> pubmed

Kiessling, A., Weigle, B., Füssel, S., Ebner, R., Meye, A., Rieger, M.A., Schmitz, M., Temme, A., Bachmann, M., Wirth, M.P., and Rieber, E.P. (2005)
D-TMPP: a novel androgen-regulated gene preferentially expressed in prostate and prostate cancer that is the first characterised member of an eukaryotic gene family.
Prostate, 64, 387-400.
> pubmed

Rieger, M.A. , Ebner, R., Bell , D.R., Kiessling, A., Rohayem, J., Schmitz, M., Temme, A., Rieber, E.P., and Weigle, B. (2004)
Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma.
Cancer Res., 64, 2357-2364.
> pubmed

Kiessling, A., Stevanovic, S., Füssel, S., Weigle, B., Rieger, M.A., Temme, A., Rieber, E.P., and Schmitz, M. (2004)
Identification of an HLA-A*0201-restricted T cell epitope derived from the prostate cancer-associated protein prostein.
Br. J. Cancer, 90, 1034-1040.
> pubmed

Weigle, B., Kiessling, A., Ebner, R., Fuessel, S., Temme, A., Schmitz, M., Rieger, M.A., Ockert, D., Wirth, M.P., and Rieber, E.P. (2004)
D-PCa-2: a novel transcript specifically expressed in human normal prostate and prostate cancer.
Int. J. Cancer, 109, 882-892.
> pubmed

Weigle, B., Fuessel, S., Ebner, R., Temme, A., Schmitz, M., Schwind, S., Kiessling, A., Rieger, M.A., Meye, A., Bachmann, M., Wirth, M.P., and Rieber, E.P. (2004)
D-GPCR: a novel putative G protein-coupled receptor overexpressed in prostate cancer and prostate.
Biochem. Biophys. Res. Commun. , 322, 239-249.
> pubmed

Temme, A., Rieger, M., Reber, F., Lindemann, D., Weigle, B., Diestelkoetter-Bachert, P., Ehninger, G., Tatsuka, M., Terada, Y., and Rieber, E.P. (2003)
Localisation, dynamics and function of Survivin revealed by expression of functional SurvivinDsRed fusion proteins in the living cell.
Mol. Biol. Cell., 14, 78-92.
> pubmed