Seibert, M., Koschade, S.E., Stolp, V., Häupl, B., Wempe, F., Serve, H., Kurrle, N.*, Schnütgen, F.*, and von Metzler, I.* (2023) The MYC-Regulated RNA Binding Proteins hnRNPC and LARP1 are Drivers of Multiple Myeloma Cell Growth and Disease Progression and Negatively Predict Patient Survival. Cancers 15, 5508
Alshamleh, I., Kurrle, N., Makowka, P., Bhayadia, R., Kumar, R., Süsser, S., Seibert, M., Ludig, D., Wolf, S., Koschade, S., Stoschek, K., Kreitz, J., Fuhrmann, D., Toenges, R., Notaro, M., Comoglio, F., Schuringa, J.J., Berg, T., Brüne, B., Krause, D., Klusmann, J.H., Oellerich, T., Schnütgen, F.*, Schwalbe, H.*, and Serve, H.* (2023) PDP1 is a key metabolic gatekeeper and modulator of drug resistance in FLT3-ITD-positive acute myeloid leukemia. Leukemia 37, 2367-2382
Scheich, S., Chen, J., Liu, J., Schnütgen, F., Enssle, J., Ceribelli, M., Thomas, C.J., Choi, J., Morris, V., Hsiao, T., Nguyen, H., Wang, B., Bolomsky, A., Phelan, J.D., Corcoran, S., Young, R.M., Häupl, B., Wright, G.W., Huang, D.W., Ji, Y., Yu, X., Xu, W., Yang, Y., Zhao, H., Muppidi, J., Pan, K.-T., Oellerich, T., and Staudt, L.M. (2023) Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas. Cancer Discovery 13, 1862-1883
Edwards-Faret, G., de Vin, F., Slezak, M., Karaman, R., Gollenbeck, L., Shinmyo, Y,. Batiuk, M.Y., Menacho Pando, C., Urschitz, J., Rincon, M.Y., Moisyadi, S., Schnütgen, F., Kawasaki, H., Schmucker, D., & Holt, M.G. (2023) A new technical approach for cross-species examination of neuronal wiring and adult neuron-glia functions. Neuroscience 508, 40-51
Nold, S.P., Sych, K., Imre, G., Fuhrmann, D., Pfeilschifter, J., Vutukuri, R., Schnütgen, F., Wittig, I., Frank, S. & Goren, I. (2023) Reciprocal abrogation of PKM isoforms: contradictory outcomes and differing impact of splicing signal on CRISPR/Cas9 mediated gene editing in keratinocytes. FEBS1111/febs.16625
Seibert, M., Kurrle, N., Stolp, V., Nürnberger, H., Tzschentke, S., Börner, L., Wempe, F., Serve, H., & Schnütgen, F. (2022) Selection-free endogenous tagging of cell lines by bicistronic co-expression of the surface antigen NGFR. MethodsX 9,101929
Vilaplana-Lopera, N., Cuminetti, V., Almaghrabia, R., Papatzikas, G., Rout, A., Jeeves, M., González, E., Alyayhawi, Y., Cunningham, A., Erdem, A., Schnütgen, F., Raghavan, M., Potluri, S., Cazier, J.-B., Schuringa, J.J., Reed, M.A.C., Arranz, L., Günther, U.L., and Garcia, P. (2022) Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells. Elife 11, e75908
Jayavelu, A.K., Wolf, S., Buettner, F., Alexe, G., Häupl, B., Comoglio, F., Schneider, C., Doebele, C., Fuhrmann, D., Wagner, S., Donato, E., Andresenm C., Wilke, A., Zindel, A., Jahn, D., Splettstoesser, B., Plessmann, U., Münch, S., Abou Elardat, K., Makowka, P., Acker, F., Enssle, J., Cremer, A., Schnütgen, F., Kurrle, N., Chapuy, B., Löber, J., Hartmann, S., Wild, P., Wittig, I., Hünschmann, D., Kaderali, L., Cox, J., Brüne, B., Röllig, C., Thiede, C., Steffen, B., Bornhäuser, M., Trumpp, A., Urlaub, H., Stegmaier, K., Serve, H., Mann, M., Oellerich, T. (2022) The Proteogenomic Subtypes of Acute Myeloid Leukemia. Cancer Cell 40, 301-317
Wilke, A., Doebele, C., Zindel, A., Lee, K.S., Rieke, S., Ceribelli, M., Comoglio, F., Phelan, J., Wang, J., Pikman, A., Jahn, D., Häupl, B., Schneider, C., Scheich, S., Tosto, F., Bohnenberger, H., Stauder, P., Schnütgen, F., Słabicki, M., Coulibaly, Z., Wolf, S., Bojarczuk, K., Chapuy, B., Brandts, B., Stroebel, P., Lewis, C., Engelke, M., Xu, X., Kim, H., Dang, T.H., Schmitz, R., Hodson, D.J., Stegmaier, K., Urlaub, H., Serve, H., Schmitt, C., Kreuz, F., Knittel, G., Rabinowitz, J., Reinhardt, H., Vander Heiden, M., Thomas, C., Staudt, L., Zenz, T., and Oellerich, T. (2022) SHMT2 inhibition disrupts the TCF3 TCF3 transcriptional survival program in Burkitt lymphoma. Blood, doi: 10.1182/blood.2021012081
Koschade, SE., Klann, K., Shaid, S., Vick, B., Stratmann, JA., Thölken, M., Meyer, LM., Nguyen, TD., Campe, J., Moser, LM., Hock, S., Baker, F., Meyer, CT., Wempe, F., Serve, H., Ullrich, E., Jeremias, I., Münch, C., Brandts, CH. Translatome proteomics identifies autophagy as a resistance mechanism to on-target FLT3 inhibitors in acute myeloid leukemia. Leukemia 36(1):2396-2407
Clees, A., Stolp, V., Häupl, B., Fuhrmann, D.C., Wempe, F., Seibert, M., Weber, S., Banning, A., Tikkanen, R., Williams, R., Brüne, B., Serve, H., Schnütgen, F.*, von Metzler, I.*, and Kurrle, N.* (2021) Identification of the Cysteine Protease Legumain as a Potential Chronic Hypoxia-Specific Multiple Myeloma Target Gene. Cells 11, 292
Karakitsou, E, Foguet, C., Contreras Mostazo, M.G., Kurrle, N., Schnütgen, F., Michaelis, M., Cinatl, J., Marin, S., and Cascante, M. (2021) Genome-scale integration of transcriptome and metabolome unveils squalene synthase and dihydrofolate reductase as targets against AML cells resistant to chemotherapy. Computational and Structural Biotechnology Journal. 10.1016/j.csbj.2021.06.049
Nimbarte, V.D., Wirmer-Bartoschek, J., Gande, S.L., Alshamleh, I., Seibert, M., Nasiri, H.R., Schnütgen, F., Serve, H., and Schwalbe, H. (2021) Fragment-based Lead Discovery and Design of Indole-derived c-Myc Promoter G-Quadruplex Binders to Down-regulate c-Myc Expression in Cancer Cells. ChemMedChem 1002/cmdc.202000835
Malkomes, P., Lunger, I., Oppermann, E., Abou-El-Ardat, K., Oellerich, T., Guenther, S., Canbulat, C., Bothur, S., Schnütgen, F., Yu, W., Wingert, S., Haetscher, N., Catapano, C., Dietz, M.S., Heilemann, M., Kvasnicka, H.-M., Holzer, K., Serve, H., Bechstein, W.O., and Rieger, M. (2021) Transglutaminase 2 promotes tumorigenicity of colon cancer cells by inactivation of the tumor suppressor p53. Oncogene 40, 4352-4367
Seibert, M., Kurrle, N., Schnütgen, F., and Serve, H. (2021) Amino acid sensory complex proteins in mTORC1 and macroautophagy regulation. Matrix Biol. doi: 10.1016/j.matbio.2021.01.001
Makowka, P., Stolp, V., Stoschek K., Serve H. (2021) Molecular determinants of therapy response of venetoclax-based combinations in acute myeloid leukemia. Biol Chem. 402(12):1547-1564
Weber, S., Parmon, A., N., Schnütgen, F., and Serve, H. (2020) The clinical significance of iron overload and iron metabolism, in myelodysplastic syndrome and acute myeloid leukemia. Front. Immunol. 11, 627-662
Contreras Mostazo, M.G., Kurrle, N., Casado, M., Fuhrmann, D., Alshamleh, I., Häupl, B., Martín-Sanz, P., Brüne, B., Serve, H., Schwalbe, H., Schnütgen, F.*, Marin, S.*, and Cascante, M.* (2020) Metabolic plasticity is an essential requirement of acquired tyrosine kinase inhibitor resistance in Chronic Myeloid Leukemia. Cancers 12, 3443
Alshamleh, I., Krause, N., Richter, C., Kurrle, N., Serve, H., Günther, UL., Schwalbe, H. (2020) Real-time NMR spectroscopy for studying metabolism. Angew Chem Int Ed Engl. 59(6):2304-2308
Kumar, R., Pereira, R.S., Zanetti, C., Minciacchi, V.R., Merten, M., Meister, M., Niemann, J., Dietz, M.S., Rüssel, N., Schnütgen, F., Tamai, M., Akahane, K., Inukai, T., Oellerich, T., Kvasnicka, H.M., Pfeifer, H., Nicolini, F.E., Heilemann, M., Van Etten, R.A., & Krause, D. (2020) Specific, targetable interactions with the microenvironment influence imatinib-resistant chronic myeloid leukemia. Leukemia 34, 2087-2101
Kreitz, J., Schönfeld, C., Seibert, M., Stolp, V., Alshamleh, I., Oellerich, T., Steffen, B., Schwalbe, H., Schnütgen, F., Kurrle, N., & Serve, H. (2019) Metabolic Plasticity of Acute Myeloid Leukemia. Cells 8, 805
Fuhrmann, D., Olesch, C., Kurrle, N., Schnütgen, F., Zukunft, S., Fleming, I., & Brüne, B. (2019) Chronic hypoxia enhances β-oxidation-dependent electron transport via electron transferring flavoproteins. Cells 8, 172
Thöne, F.M.B., Kurrle, N., von Melchner, H., & Schnütgen, F. (2019) CRISPR/Cas9-mediated generic protein tagging in mammalian cells. Methods 164-165, 59-66
Barth, J., Abou-El-Ardat, K., Dalic, D., Kurrle, N., Maier, AM., Mohr, S., Schütte, J., Vassen, L., Greve, G., Schulz-Fincke, J., Schmitt, M., Tosic, M., Metzger, E., Bug, G., Khandanpour, C., Wagner, SA., Lübbert, M., Jung, M., Serve, H., Schüle, R., Berg, T. (2019) LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML. Leukemia 33(6):1411-1426
